POEMS syndrome is a rare paraneoplastic disorder that is named after its multi-systemic presentation of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Though the predominant feature is progressive polyneuropathy, bilateral optic disc edema is present in the majority of patients. Not only do eye care providers play a significant role in the treatment of the patient, but also measure treatment response. Given the high incidence of bilateral optic disc edema in POEMS syndrome, eye examinations are indicated at the time of diagnosis. Further, ocular manifestations of POEMS syndrome are reflective of the disease severity and offer prognostic value. POEMS syndrome affects multiple aspects of a patients functionality therefore, a multidisciplinary holistic approach to patient care provides the best outcome.
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